The development of vaccine has achieved an evolutionary path. With the help of pharmaceutical nanotechnology we can formulate the efficient vaccine delivery systems that can maintain a sustained release to induce the immune-stimulatory properties of the vaccine. Formulations based on nanotechnology offer multiple advantages in vaccine developments. Nanocarriers such as polymeric particles, liposomes, lipid nanoparticles, virosomes etc. help in improving the immunogenicity in the new generation of vaccines. This nanocarrier systems help to improve vaccine stability, protect the vaccines from degradation, help in targeting of the antigen to the antigen presenting cells (APCs) and provide adjuvant effect.